Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder.

نویسندگان

  • H Ujike
  • A Yamamoto
  • Y Tanaka
  • Y Takehisa
  • M Takaki
  • T Taked
  • M Kodama
  • S Kuroda
چکیده

To investigate a possible involvement of expanded triplet repeats of genome in the genomes of patients with endogenous psychoses, we examined a CAG repeat polymorphism in the coding region of the KCNN3 gene in schizophrenia, schizoaffective disorder, bipolar disorder and controls of the Japanese population. There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran

Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association ...

متن کامل

Effects of metformin on weight loss and metabolic control in obese patients with schizophrenia and schizoaffective disorder: a randomized, double-blind, controlled clinical trial

Abstract Objective: The effect of metformin on weight changes and some metabolic parameters in patients with schizophrenia and schizoaffective disorder was investigated in this study. Methods:  This study, performed during 2018-2019, was a randomized, double-blind, controlled clinical trial. A total of 66 obese patients (BMI≥27) with schizophrenia and schizoaffective disorder, hospitalized in...

متن کامل

Effect of Memantine on Positive Sign in Patients with Schizophrenia and Schizoaffective Disorders: A Randomized Double Blind Placebo Controlled Trial

Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with an...

متن کامل

The Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II

Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...

متن کامل

The Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II

Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Psychiatry research

دوره 101 3  شماره 

صفحات  -

تاریخ انتشار 2001